01 - In a small bowl, combine salt, pepper, paprika, garlic powder, and onion powder. Mix until evenly blended.
02 - Sprinkle both sides of each tilapia fillet evenly with the seasoning blend, pressing gently so the spices adhere to the surface.
03 - For extra crispiness, lightly dredge the seasoned fillets in cornmeal or gluten-free flour, shaking off any excess.
04 - Heat olive oil or butter in a large nonstick skillet over medium-high heat until the fat shimmers and just begins to smoke slightly.
05 - Carefully place the fillets in the hot skillet, working in batches if necessary to avoid crowding. Cook for 3–4 minutes on the first side until golden and the fish releases easily from the pan.
06 - Gently flip each fillet using a fish spatula and cook for another 2–3 minutes until the flesh is opaque throughout and flakes easily with a fork.
07 - Transfer to warm plates and serve immediately with fresh lemon wedges alongside steamed vegetables, salad, or rice.