01 - Preheat oven to 400°F and line a baking sheet with parchment paper.
02 - Combine ground beef, cream cheese, Italian seasoning, garlic powder, onion powder, salt, and pepper in a mixing bowl. Mix until thoroughly incorporated.
03 - Divide beef mixture into 8 equal portions. Flatten each portion on parchment paper into a 5x3 inch rectangle.
04 - Place pepperoni slices and shredded mozzarella in the center of each flattened rectangle.
05 - Carefully roll each rectangle around the filling, pinching edges to seal and prevent cheese leakage during baking.
06 - Place roll ups seam side down on prepared baking sheet. Sprinkle parmesan cheese evenly over the top of each roll.
07 - Bake for 15 minutes until beef is fully cooked and cheese is melted and bubbly.
08 - Serve hot with marinara sauce on the side for dipping, if desired.