01 - Heat a large skillet over medium-high heat. Add the ground beef, salt, pepper, smoked paprika, and garlic powder. Break up the meat and stir occasionally until browned and cooked through, about 7–8 minutes. Drain excess fat if needed.
02 - While the beef cooks, whisk together the mayonnaise, ketchup, mustard, pickle relish, vinegar, smoked paprika, salt, and pepper in a small bowl until well combined. Set aside.
03 - Divide the chopped romaine lettuce evenly among four large serving bowls to create the base.
04 - Top each bowl with equal portions of cooked ground beef, cherry tomatoes, cheddar cheese, red onion, pickle slices, and diced avocado.
05 - Drizzle each bowl with the prepared burger sauce just before serving. Serve immediately while the beef is still warm.